Acute inflammation triggered by two lightweight hernia meshes: a comparative in vitro and retrospective cohort study

PURPOSE: Retro-muscular mesh augmentation is standard for repairing abdominal incisional or larger primary hernia. A wide variety of meshes with diverse properties are available. The knowledge on the immune-modulating effects of meshes is, however, insufficient. This study investigates the impact of two widely used lightweight meshes, ULTRAPRO(®) and ProGrip™, on macrophage activation (in vitro), systemic inflammation (in vivo), patient perioperative and long-term outcomes. METHODS: Human THP-1 cell-derived macrophages were cultured in absence and presence of ULTRAPRO(®) or ProGrip™ meshes. The release of pro-inflammatory cytokines, interleukin (IL)-1

• Reichert, M.
• Massambo, B.
• Amati, A. L.
• Grau, V.
• Richter, K.
• Hecker, A.