Stratifying GAP Stages by MUC5B rs35705950 T-Allele Carriage Refines Survival Prediction in IPF

The genetic contribution to idiopathic pulmonary fibrosis (IPF) has become increasingly evident, enabling its translation into clinical practice. MUC5B rs35705950 has emerged as a promising prognostic biomarker. The gender-age-physiology (GAP)-model is regularly used for IPF survival prediction. In this retrospective real-world study, GAP-stages were stratified by MUC5B T-allele carriage. European patients with IPF were included in a discovery (n = 663), and replication (n = 738) cohort. The GAP+MUC5B-model was significantly more accurate compared to the GAP-model (all cohorts p < 0.001), with a modest improvement in discrimination (

• van der Vis, J. J.
• Prasse, A.
• Renzoni, E. A.
• Stock, C. J. W.
• Maher, T. M.
• Bonella, F.
• Borie, R.
• Crestani, B.
• Wuyts, W. A.
• Molyneaux, P. L.
• Kelder, J. C.
• Grutters, J. C.
• van Moorsel, C. H. M.