Science and Research

[Molecular-allergological aspects of allergen-specific immunotherapy]

Allergen-specific immunotherapy (SIT) does not achieve 100% efficacy, nor is there a reliable marker for therapy failure. However, advances in molecular allergology over the past few years have allowed a significantly improved characterization of the patients using molecular-allergological analysis methods (molecular phenotyping). Thus, major and minor allergens can be identified. In addition, the marker allergens for the severity of an allergic reaction, the pathological and therapeutic predictive marker allergens, and sensitization patterns are identified.

  • Jappe, U.

Keywords

  • Allergens/*immunology/*therapeutic use
  • Animals
  • Cytokines/*immunology
  • Desensitization, Immunologic/*methods
  • Humans
  • Hypersensitivity/diagnosis/*immunology/*therapy
  • Biomarker
  • Desensitization, immunologic
  • Major allergens
  • Marker allergens
  • Minor allergens
Publication details
DOI: 10.1007/s00105-017-3958-8
Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
Pages: 271-281 
Number: 4
Work Type: Review
Location: ARCN
Disease Area: AA
Partner / Member: FZB
Access-Number: 28293695
See publication on PubMed

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