Interleukin-2-induced skin inflammation

Recombinant human IL-2 has been used to treat inflammatory diseases and cancer; however, side effects like skin rashes limit the use of this therapeutic. To identify key molecules and cells inducing this side effect, we characterized IL-2-induced cutaneous immune reactions and investigated the relevance of CD25 (IL-2 receptor

• Sommer, C.
• Cohen, J. N.
• Dehmel, S.
• Neuhaus, V.
• Schaudien, D.
• Braun, A.
• Sewald, K.
• Rosenblum, M. D.