Science and Research

The eATP/P2×7R Axis Drives Quantum Dot-Nanoparticle Induced Neutrophil Recruitment in the Pulmonary Microcirculation

Exposure to nanoparticles (NPs) is frequently associated with adverse cardiovascular effects. In contrast, NPs in nanomedicine hold great promise for precise lung-specific drug delivery, especially considering the extensive pulmonary capillary network that facilitates interactions with bloodstream-suspended particles. Therefore, exact knowledge about effects of engineered NPs within the pulmonary microcirculation are instrumental for future application of this technology in patients. To unravel the real-time dynamics of intravenously delivered NPs and their effects in the pulmonary microvasculature, we employed intravital microscopy of the mouse lung. Only PEG-amine-QDs, but not carboxyl-QDs triggered rapid neutrophil recruitment in microvessels and their subsequent recruitment to the alveolar space and was linked to cellular degranulation, TNF-

  • Li, C.
  • Liu, Q.
  • Han, L.
  • Zhang, H.
  • Immler, R.
  • Rathkolb, B.
  • Secklehner, J.
  • de Angelis, M. H.
  • Yildirim, AÖ
  • Zeuschner, D.
  • Nicke, A.
  • Carlin, L. M.
  • Sperandio, M.
  • Stoeger, T.
  • Rehberg, M.

Keywords

  • eATP P2X7 axis
  • innate immune response
  • intravital microscopy
  • lung
  • nanoparticles
Publication details
DOI: 10.1002/advs.202404661
Journal: Adv Sci (Weinh)
Pages: e2404661 
Work Type: Original
Location: CPC-M
Disease Area: PLI
Partner / Member: HMGU, KUM
Access-Number: 39364760

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