This post-market, prospective, single arm, observational study observes the effectiveness and safety of the BF-UCP190F bronchoscope and ViziShot 2 25G needle for visualizing and sampling lesions in the inner and middle 2/3 of the hilar–costal diameter of the lung at 2 study sites in Germany. This study aims to enroll 200 evaluable subjects. The primary enpoint is the ability to visualize and sample a priori defined lesion in the inner or middle third of the lung. Secondary enpoints include the diagnostic yield, the ability to visualize and smaple lymph nodes and pulmonary parenchymal lesions, the ability to obtain adequate tissue samples required for molecular testing, the need for salvage procedures to obtain material, diagnostic accuracy measures ( diagnotic sensitivity and specificity, PPV, NPV, sensitivity for malignancy), prodedure and lesion characteristics (duration, intrumentation used, nodule spiculation, opacity, size, cavitation, lobulation, location and position)
