This study aims for identifying transcriptome- and proteome-based signatures as well as bio-markers and genetic polymorphisms asso-ciated with community- or hospital-acquired pneumonia in CAP patients. Of particular interest are markers of the transition from uncomplicated pneumonia to severe pneumonia and pneumonia with an increased risk of sepsis. By linking well-defined clinical phenotypes with data on DNA, RNA, and proteins obtained from peripheral blood using high-throughput methods, molecular disease characteristics can be correlated with clinical aspects of the infection, thus allowing the identification of fingerprints.
The completion date is a rough estimate as the study will be completed after the documentation of the last follow-up visit of the last of approximately 300 patients.
