Science and Research

NEOpredict-EGFR: Preoperative amivantamab or amivantamab and carboplatin/pemetrexed treatment in patients with resectable non-small-cell lung cancer harboring oncogenic EGFR mu-tations

The primary objective of this study is to determine the feasibility of four weeks of preoperative antibody therapy with amivantamab. Amivantamab will be administered as monotherapy (stage 1), and combined with carboplatin/pemetrexed chemotherapy (stage 2). Study treatment is followed by standard of care surgery, and (if clinically indicated) standard of care adjuvant therapy (chemothera-py, radiotherapy, EGFR tyrosine kinase inhibitor therapy) in patients with early stage or locally advanced non-small-cell lung cancer har-boring oncogenic EGFR mutations who are eligible for curative re-section

Study details
Study-ID: NCT06784791
Study-ID: NCT06784791
DZL Disease Area: LC
DZL Disease Area: LC
Study Type: Interventional
Study Type: Interventional
DZL Role: DZL recruiting center
DZL Role: DZL recruiting center
Funding: Externally - public
Funding: Externally - public
DZL Participating Sites: TLRC
DZL Participating Sites: TLRC
Start Date: 06.11.2024
Completion Date: 31.12.2027
Status: Recruiting
Status: Recruiting
DZL recruiting center
Link to Study


chevron-down