Science and Research

An Open Label, Multicenter, Phase 1b/2a Study to Evaluate Efficacy, Safety, Tolerability, and Pharmacokinetics of the ATR inhibitor M1774 in Combination With Cemiplimab in Participants With Non-Squamous NSCLC That Has Progressed on Prior Anti-PD-(L)1 and Platinum-based Therapies (DDRiver NSCLC-322) MS201924_0022 DDRiver.

This is an Open-label, multicenter clinical study conducted in two Phases to establish the efficacy, safety, tolerability, and pharmacokinetics of the ataxia telangiectasia mutated and Rad3-related protein kinase (ATR) inhibitor Tuvusertib in Combination with Cemiplimab in Participants with Non-Squamous Non-Small Cell Lung Cancer (nsqNSCLC) that has Progressed on Prior Anti-PD-(L)1 and Platinum-based Therapies..

Study details
Study-ID: NCT05882734, 2022-502010-85
Study-ID: NCT05882734, 2022-502010-85
DZL Disease Area: LC, PH
DZL Disease Area: LC, PH
Study Type: Interventional
Study Type: Interventional
DZL Role: DZL recruiting center
DZL Role: DZL recruiting center
Funding: DZL
Funding: DZL
DZL Participating Sites: UGMLC
DZL Participating Sites: UGMLC
Start Date: 13.09.2023
Completion Date: 30.03.2026
Status: Active / not recruiting
Status: Active / not recruiting
DZL recruiting center
Link to Study


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