The primary objective of the AGNES-19 trial is to evaluate if improvement of vascular integrity with Adrecizumab on top of standard of care (SOC) is superior to placebo/ control substance (NaCl 0.9%) on top of SOC in reduction of the endpoint ”time to clinical improvement” until day 28 in patients with moderate to severe COVID-19. The secondary objectives of the AGNES-19 trial intend to evaluate the effect of Adrecizumab in com-parison to placebo, with respect to safety and tolerability of Adrecizumab on top of SOC in patients with moderate to severe COVID-19, clinical status at day 28, all-cause mortality, rate of new invasive mechanical ventilation, length of invasive mechanical ventilation, length of initial stay at ICU, rate of renal replacement therapy, change in SOFA score, clinical status according to ordinal WHO scale for COVID-19, and life quality as assessed by EQ5D.
