Science and Research

A Randomized Prospective Trial of Adjuvant Chemotherapy in Patients with Completely Resected Stage I or IIA Non-Squamous Non-Small Cell Lung Cancer Identified as High or Intermediate Risk by a 14-Gene Prognostic Assay.

The primary objective of this study is to compare DFS in patients with completely resected (R0), stage I or IIA non-squamous NSCLC who are found to be at High or Intermediate Risk by the 14-Gene Prognostic Assay and who are subsequently either randomized to observation or randomized to and are willing to initiate adjuvant therapy with four cycles of a standard NSCLC platinum-based doublet (i.e., mITT population), so as to document the benefit of personalizing patient care based on molecular prognostic data.

Study details
Study-ID: 2024-511185-37-00
Study-ID: 2024-511185-37-00
DZL Disease Area: LC
DZL Disease Area: LC
Study Type: Interventional
Study Type: Interventional
DZL Role: DZL recruiting center
DZL Role: DZL recruiting center
Funding: Externally - industry
Funding: Externally - industry
DZL Participating Sites: BREATH
DZL Participating Sites: BREATH
Start Date: 26.02.2024
Completion Date: 10.02.2025
Status: Active / not recruiting
Status: Active / not recruiting
DZL recruiting center


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