Science and Research

A Phase 3 Study Evaluating the Pharmacokinetics, Safety, and Tolerability of VX‑121/Tezacaftor/Deutivacaftor Triple Combination Therapy in Cystic Fibrosis Subjects 1 Through 11 Years of Age

The purpose of this study is to evaluate the pharmacokinetics, safety, tolerability and efficacy of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA) in CF participants with at least 1 triple combination responsive (TCR) mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. To evaluate the safety and tolerability of VX-121/TEZ/D-IVA

Study details
Study-ID: NCT05422222, 2024-513754-29-00
Study-ID: NCT05422222, 2024-513754-29-00
DZL Disease Area: CFBE
DZL Disease Area: CFBE
Study Type: Interventional
Study Type: Interventional
DZL Role: DZL recruiting center, DZL on steering board
DZL Role: DZL recruiting center, DZL on steering board
Funding: Externally - industry
Funding: Externally - industry
DZL Participating Sites: BIH / Charité - Associated Partner, BREATH
DZL Participating Sites: BIH / Charité - Associated Partner, BREATH
Start Date: 20.02.2023
Completion Date: 30.06.2030
Status: Recruiting
Status: Recruiting
DZL recruiting center, DZL on steering board
Link to Study


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