A Phase 3, open-label study evaluating the long-term safety and efficacy of VX-445 combination therapy in subjects with cystic fibrosis who are homozygous or heterozygous for the F508del mutation (VX17-445-105)

The study evaluates the long-term safety and tolerability of VX-445 in triple combination (TC) with tezacaftor (TEZ) and ivacaftor (IVA) in subjects with cystic fibrosis (CF) who are homozygous or heterozy-gous for the F508del mutation.