Science and Research

Estimation of an Exposure Threshold Value for Compensation of Silica-Induced COPD Based on Longitudinal Changes in Pulmonary Function

(1) Background: To estimate the cumulative exposure to respirable crystalline silica (RCS) that reduces lung function to an extent corresponding with airway obstruction equivalent to chronic obstructive pulmonary disease (COPD). (2) Methods: The study is based on a miners' cohort with longitudinal data on lung function and RCS exposure. Random-effects linear regression models, allowing for a possible threshold concerning the exposure concentration were used to analyze the impact of RCS on the ratio of forced expiratory volume in 1 s and forced vital capacity (FEV(1)/FVC). The proposed threshold is the amount of RCS resulting in a decrease in FEV(1)/FVC from the expected value to the lower limit of normal. (3) Results: The analysis shows that a threshold model fits the data significantly better than the usual linear model. The estimated threshold value for the exposure concentration is 0.089 mg/m(3). Using this threshold, the estimate for the corresponding reference dose for RCS is 2.33 mg/m(3)·y. (4) Conclusions: The analysis confirmed that RCS has a negative impact on lung function. The effect is primarily due to exposure above a concentration threshold of 0.1 mg/m(3). It is recommended that COPD should be compensated as an occupational disease if cumulative exposure was at least 2 mg/m(3)·y above this threshold.

  • Möhner, M.
  • Nowak, D.

Keywords

  • *chronic obstructive pulmonary disease
  • *compensation
  • *epidemiology
  • *respirable crystalline silica
  • *threshold models
  • this manuscript for publication is that of the authors.
Publication details
DOI: 10.3390/ijerph17239040
Journal: Int J Environ Res Public Health
Number: 23
Work Type: Original
Location: CPC-M
Disease Area: COPD
Partner / Member: LMU
Access-Number: 33291582

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