Primary Epstein-Barr-Virus (EBV)-associated pulmonary lymphoepithelioma-like carcinoma (LELC) is an aggressive rare cancer. Higher incidences have been observed in Asian sub-populations. Multimodal treatment paradigms have emerged as promising novel strategies in the management of advanced NSCLC. In this report, we describe the case of a 34-year-old female patient of Asian origin with a post-partum initial diagnosis of pulmonary LELC. Multimodal treatment with chemoimmunotherapy and hypofractionated irradiation to the primary tumour and main metastatic sites led to a favourable response demonstrating that radiotherapy may potentially augment anti-tumour immunity. To the best of our knowledge, this is the first case report on this novel therapy strategy of multi-site hypofractionated radiotherapy and chemoimmunotherapy for metastatic pulmonary EBV-associated LELC.
- Pazos, M.
- Eze, C.
- Kahnert, K.
- Delius, M.
- Tufman, A.
- Alba-Alejandre, I.
- Unterrainer, M.
- Neumann, J.
- Kirchner, T.
- Manapov, F.
Keywords
- EBV-associated lymphoepithelioma-like lung carcinoma
- Lelc
- chemoimmunotherapy
- lung cancer in pregnancy
- multi-site radiation therapy
