Science and Research

The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions

Neutrophils are the predominant immune cells in human blood possessing heterogeneity, plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed tissue in response to stimuli are tightly regulated processes. Alpha1-Antitrypsin (AAT), an acute phase protein, is one of the potent regulators of neutrophil activation via both -protease inhibitory and non-inhibitory functions. This review summarizes our current understanding of the effects of AAT on neutrophils, illustrating the interplay between AAT and the key effector functions of neutrophils.

  • Janciauskiene, S.
  • Wrenger, S.
  • Immenschuh, S.
  • Olejnicka, B.
  • Greulich, T.
  • Welte, T.
  • Chorostowska-Wynimko, J.

Keywords

  • Alpha1-Antitrypsin
  • acute phase protein
  • cytokines
  • inflammation
  • innate immunity
  • neutrophil degranulation
  • neutrophil granulocyte
  • proteases
Publication details
DOI: 10.3389/fphar.2018.00341
Journal: Frontiers in pharmacology
Pages: 341 
Work Type: Review
Location: BREATH, UGMLC
Disease Area: COPD
Partner / Member: MHH, UMR
Access-Number: 29719508
See publication on PubMed

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