SLPI deficiency alters airway protease activity and induces cell recruitment in a model of muco-obstructive lung disease

Secretory leukocyte protease inhibitor (SLPI) is an important cationic protein involved in innate airway immunity and highly expressed in mucosal secretions, shown to target and inhibit neutrophil elastase (NE), cathepsin G and trypsin activity to limit proteolytic activity. In addition to the potent anti-protease activity, SLPI has been demonstrated to exert a direct anti-inflammatory effect, which is mediated via increased inhibition and competitive binding of NF-

• Brown, R.
• Dougan, C.
• Ferris, P.
• Delaney, R.
• Houston, C. J.
• Rodgers, A.
• Downey, D. G.
• Mall, M. A.
• Connolly, B.
• Small, D.
• Weldon, S.
• Taggart, C. C.