Impact of (68)Ga-FAPI PET/CT Imaging on the Therapeutic Management of Primary and Recurrent Pancreatic Ductal Adenocarcinomas

Pancreatic ductal carcinoma (PDAC) is a highly lethal cancer, and early detection and accurate staging are critical to prolonging survival. PDAC typically has a prominent stroma including cancer-associated fibroblasts that express fibroblast activation protein (FAP). FAP is a new target molecule for PET imaging of various tumors. In this retrospective study, we describe the clinical impact of PET/CT imaging using (68)Ga-labeled FAP-inhibitors ((68)Ga-FAPI PET/CT) in 19 patients with PDAC (7 primary, 12 progressive/recurrent). Methods: All patients underwent contrast-enhanced CT (ceCT) for TNM staging before (68)Ga-FAPI PET/CT imaging. PET scans were acquired 60 min after administration of 150-250 MBq of (68)Ga-labeled FAP-specific tracers. To characterize (68)Ga-FAPI uptake over time, additional scans after 10 or 180 min were acquired in 6 patients. SUV(max) and SUV(mean) values of PDAC manifestations and healthy organs were analyzed. The tumor burden according to (68)Ga-FAPI PET/CT was compared with TNM staging based on ceCT and changes in oncologic management were recorded. Results: Compared with ceCT, (68)Ga-FAPI PET/CT results led to changes in TNM staging in 10 of 19 patients. Eight of 12 patients with recurrent/progressive disease were upstaged, 1 was downstaged, and 3 had no change. In newly diagnosed PDAC, 1 of 7 patients was upstaged, and the staging of 6 patients did not change. Changes in oncologic management occurred in 7 patients. Markedly elevated uptake of (68)Ga-FAPI in PDAC manifestations after 1 h was seen in most cases. Differentiation from pancreatitis based on static imaging 1 h after injection was challenging. With respect to imaging after multiple time points, PDAC and pancreatitis showed a trend for differential uptake kinetics. Conclusion: (68)Ga-FAPI PET/CT led to restaging in half of the patients with PDAC and most patients with recurrent disease compared with standard of care imaging. The clinical value of (68)Ga-FAPI PET/CT should be further investigated.

• Röhrich, M.
• Naumann, P.
• Giesel, F. L.
• Choyke, P. L.
• Staudinger, F.
• Wefers, A.
• Liew, D. P.
• Kratochwil, C.
• Rathke, H.
• Liermann, J.
• Herfarth, K.
• Jäger, D.
• Debus, J.
• Haberkorn, U.
• Lang, M.
• Koerber, S. A.