Science and Research

The low density lipoprotein receptor-related protein (LRP) 1 and its function in lung diseases

The low density lipoprotein receptor-related protein (LRP) 1 is a ubiquitously expressed, versatile cell surface transmembrane receptor involved in embryonic development and adult tissue homeostasis. LRP1 binds and endocytoses a broad spectrum of over 40 ligands identified thus far, including lipoproteins, extracellular matrix proteins, proteases and protease/inhibitor complexes and growth factors. Interactions with other membrane receptors and intracellular adaptors/scaffolding proteins allow LRP1 to modulate cell migration, survival, proliferation and (trans) differentiation. Because LRP1 displays a wide-range of interactions and activities, its expression and function is temporally and spatially tightly controlled. It is not, therefore, surprising that deregulation of LRP1 production and/or activity is observed in several diseases. In this review, we will systematically examine the evidence for the role of LRP1 in human pathologies placing special emphasis on LRP1-mediated pathogenesis of the lung.

  • Wujak, L.; Markart, P.; Wygrecka, M.

Keywords

  • Humans
  • Low Density Lipoprotein Receptor-Related Protein-1/*metabolism
  • Lung Diseases/*metabolism/physiopathology
Publication details
DOI: 10.14670/HH-11-746
Journal: Histology and histopathology
Pages: 733-45 
Number: 7
Work Type: Review
Location: UGMLC
Disease Area: General Lung and Other
Partner / Member: JLU
Access-Number: 26926950
See publication on PubMed

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