Science and Research

Impact of prophylactic administration of Levosimendan on short-term and long-term outcome in high-risk patients with severely reduced left-ventricular ejection fraction undergoing cardiac surgery - a retrospective analysis

BACKGROUND: Patients with severely reduced left-ventricular ejection fraction carry a high risk of morbidity and mortality after cardiac surgery. Levosimendan can be used prophylactically in these patients having shown positive effects on short-term outcome. However, effects on long-term outcome and patient subgroups benefiting the most are unknown. We aim to address these topics with real-life data from our clinical practice. METHODS: Two hundred eigthy eight patients with preoperative LVEF
  • Grieshaber, P.; Lipp, S.; Arnold, A.; Gorlach, G.; Wollbruck, M.; Roth, P.; Niemann, B.; Wilhelm, J.; Boning, A.
  • Keywords

    • Aged
    • Aged, 80 and over
    • Atrial Fibrillation/chemically induced
    • Cardiopulmonary Bypass
    • Cardiotonic Agents/adverse effects/*therapeutic use
    • Coronary Artery Bypass/*adverse effects/mortality
    • Female
    • Humans
    • Hydrazones/adverse effects/*therapeutic use
    • Kidney/drug effects/physiology
    • Male
    • Middle Aged
    • Postoperative Complications/etiology/*prevention & control
    • Pyridazines/adverse effects/*therapeutic use
    • Retrospective Studies
    • Risk Factors
    • Stroke Volume
    • Time Factors
    • Treatment Outcome
    • Ventricular Dysfunction, Left/*complications/physiopathology
    • Cardiac surgery
    • High-risk patients
    • Levosimendan
    • Low cardiac output syndrome
    Publication details
    DOI: 10.1186/s13019-016-0556-2
    Journal: Journal of cardiothoracic surgery
    Pages: 162 
    Number: 1
    Work Type: Original
    Location: UGMLC
    Disease Area: General Lung and Other
    Partner / Member: JLU
    Access-Number: 27906091
    See publication on PubMed

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