Tumour cells can escape antiproliferative pressure by interferon-

Type I interferons (IFNs) play a central role not only in innate immunity against viral infection, but also in the antitumour response, e.g. through a direct impact on cell proliferation. Particularly for cancer arising in the context of chronic inflammation, constant exposure to IFNs may constitute a strong selective pressure during tumour evolution. Expansion of neoplastic subclones resistant to the antiproliferative effects of IFNs may contribute to immunoediting of tumours, leading to more aggressive disease. Experimental evidence for this development of IFN-insensitivity has been scarce and its molecular mechanism is unclear. In this study we demonstrate that six weeks exposure of cells to IFN-

• Hiebinger, F.
• Kudulyte, A.
• Chi, H.
• Burbano De Lara, S.
• Ilic, D.
• Helm, B.
• Welsch, H.
• Dao Thi, V. L.
• Klingmüller, U.
• Binder, M.