Quantitative analysis of chest computed tomography in alpha-1-antitrypsin deficiency

BACKGROUND: Chest quantitative computed tomography (QCT) has been used in clinical trials to monitor patients with alpha-1 antitrypsin deficiency (AATD). There is limited data on the use of quantitative computed tomography (QCT) to phenotype emphysema in AATD. METHODS: Data from patients with a reduced AATD serum level and/or at least one deficiency mutation, who underwent a chest CT scan at the Thoraxklinik, University of Heidelberg, between 03/2012 and 02/2024, were retrospectively analyzed. The patients were categorized into three groups based on their AAT serum levels: reduced to normal (> 70 mg/dl), moderate (41-70 mg/dl), and severe (

• Höger, P.
• Benholz, J.
• Weinheimer, O.
• Wielpütz, M. O.
• Heußel, C. P.
• Bischoff, A.
• Eberhardt, R.
• Buschulte, K.
• Fähndrich, S.
• Michels-Zetsche, J. D.
• Ersöz, H.
• Rivera, A. O.
• Herth, F.
• Trudzinski, F. C.