Science and Research

Outcome and safety 90 days after combined airway valve treatment of the right upper and middle lobes in patients with severe pulmonary emphysema

BACKGROUND: In COPD patients with severe right-sided emphysema, complete major and incomplete minor fissure, implantation of one-way valves in both the right upper (RUL) and middle lobes (ML) is a possible approach for endoscopic lung volume reduction. The aim of this retrospective analysis was to evaluate the response to therapy and the complication rate at 90 days (90d-FU) after combined RUL-ML valve implantation. METHODS: This retrospective, monocentric study included all patients from the Thoraxklinik Heidelberg who underwent RUL-ML valve treatment between 2012 and 2023 with available follow-up data. Quantitative chest imaging, lung function, 6-minute walking distance (6-MWD), complications and indications for re-bronchoscopies until 90d-FU were analysed. RESULTS: 28 patients underwent combined RUL-ML valve treatment, predominantly sequentially (92.86%, n = 26/28). Neither lung function nor 6MWD improved significantly in the overall cohort. However, in the subgroup with heterogeneous emphysema (71.4%, n = 20/28), FEV1 (

  • Dittrich, A. S.
  • De Pace, C. C.
  • Brock, J. M.
  • Trudzinski, F.
  • Heussel, C. P.
  • Eberhardt, R.
  • Herth, F. J. F.
  • Kontogianni, K.

Keywords

  • Humans
  • Male
  • Female
  • *Pulmonary Emphysema/physiopathology/surgery/diagnostic imaging
  • Retrospective Studies
  • Aged
  • Middle Aged
  • Treatment Outcome
  • *Pneumonectomy/adverse effects/methods
  • Severity of Illness Index
  • Time Factors
  • Follow-Up Studies
  • Bronchoscopy/methods
  • Chronic obstructive lung diseases
  • Emphysema
  • Endobronchial valve
  • Fissure
  • Intrabronchial valve
  • Lung volume reduction
  • Middle lobe
  • Right upper lobe
  • Spiration System
  • Zephyr
Publication details
DOI: 10.1186/s12931-024-03069-6
Journal: Respir Res
Pages: 4 
Number: 1
Work Type: Original
Location: TLRC
Disease Area: COPD
Partner / Member: Thorax
Access-Number: 39762833

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