Science and Research

Midregional proatrial naturetic peptide (MRproANP) and copeptin (COPAVP) as predictors of all-cause mortality in recently diagnosed mild to moderate COPD-results from COSYCONET

BACKGROUND: MRproANP and COPAVP are prognostic markers for mortality in chronic obstructive pulmonary disease (COPD). Furthermore, these biomarkers predict mortality due to cardiovascular diseases, which are important prognostically determining comorbidities in patients with COPD. However, less is known about these biomarkers in recently diagnosed mild to moderate COPD. Therefore, we analyzed these biomarkers as potential predictors of mortality in recently diagnosed mild to moderate COPD. METHODS: The blood biomarkers considered were copeptin (COPAVP), midregional adrenomedullin (MRproADM), midregional proatrial naturetic peptide (MRproANP), and fibrinogen. Analyses were performed in patients with stable "recently diagnosed mild to moderate COPD" defined by GOLD grades 0-2 and diagnosis of COPD 

  • Fähndrich, S.
  • Herr, C.
  • Teuteberg, S.
  • Alter, P.
  • Söhler, S.
  • Soriano, D.
  • Classen, J.
  • Adams, J.
  • Weinhold, V.
  • Watz, H.
  • Waschki, B.
  • Zeller, T.
  • Eichenlaub, M.
  • Trudzinski, F. C.
  • Michels, J. D.
  • Omlor, A.
  • Seiler, F.
  • Moneke, I.
  • Biertz, F.
  • Stolz, D.
  • Welte, T.
  • Kauczor, H. U.
  • Kahnert, K.
  • Jörres, R. A.
  • Vogelmeier, C. F.
  • Bals, R.

Keywords

  • Humans
  • *Pulmonary Disease, Chronic Obstructive/diagnosis
  • *Cardiovascular Diseases
  • Fibrinogen
  • Biomarkers
  • *Glycopeptides
  • Copavp
  • Copd
  • Cosyconet
  • MRproADM
  • MRproANP
  • Mortality
  • Prospective multicenter cohort study
Publication details
DOI: 10.1186/s12931-024-02690-9
Journal: Respir Res
Pages: 56 
Number: 1
Work Type: Original
Location: Assoziierter Partner, ARCN, CPC-M, BREATH, TLRC, UGMLC
Disease Area: COPD
Partner / Member: COSYCONET, Ghd, KUM, MHH, Thorax, UKHD, UMR
Access-Number: 38267944

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