Science and Research

Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19

In patients with severe #COVID19, increased levels of autoantibodies against PAR1 were found. These might serve as allosteric agonists of PAR1 on endothelial cells and platelets, and thus might contribute to the pathogenesis of microthrombosis in COVID-19. https://bit.ly/3pqM9Vv.

  • Tran, F.
  • Harris, D. M. M.
  • Scharmacher, A.
  • Graßhoff, H.
  • Sterner, K.
  • Schinke, S.
  • Käding, N.
  • Humrich, J. Y.
  • Cabral-Marques, O.
  • Bernardes, J. P.
  • Mishra, N.
  • Bahmer, T.
  • Franzenburg, J.
  • Hoyer, B. F.
  • Glück, A.
  • Guggeis, M.
  • Ossysek, A.
  • Küller, A.
  • Frank, D.
  • Lange, C.
  • Rupp, J.
  • Heyckendorf, J.
  • Gaede, K. I.
  • Amital, H.
  • Rosenstiel, P.
  • Shoenfeld, Y.
  • Halpert, G.
  • Rosenberg, A. Z.
  • Schulze-Forster, K.
  • Heidecke, H.
  • Riemekasten, G.
  • Schreiber, S.
Publication details
DOI: 10.1183/23120541.00379-2022
Journal: ERJ Open Res
Number: 4
Work Type: Original
Location: Assoziierter Partner, ARCN
Disease Area: PALI
Partner / Member: CAU, Ghd, FZB, UKSH (Kiel)
Access-Number: 36575710

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