Peripheral blood myeloid-derived suppressor cells reflect disease status in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a fibroproliferative disease with irreversible lung function loss and poor survival. Myeloid-derived suppressor cells (MDSC) are associated with poor prognosis in cancer, facilitating immune evasion. The abundance and function of MDSC in IPF is currently unknown.Fluorescence-activated cell sorting was performed in 170 patients (IPF: n=69; non-IPF interstitial lung disease (ILD): n=56; chronic obstructive pulmonary disease (COPD): n=23; healthy controls: n=22) to quantify blood MDSC and lymphocyte subtypes. MDSC abundance was correlated with lung function, MDSC localisation was performed by immunofluorescence. Peripheral blood mononuclear cell (PBMC) mRNA levels were analysed by qRT-PCR.We detected increased MDSC in IPF and non-IPF ILD compared with controls (30.99+/-15.61% versus 18.96+/-8.17%, p

Fernandez, I. E.

Greiffo, F. R.

Frankenberger, M.

Bandres, J.

Heinzelmann, K.

Neurohr, C.

Hatz, R.

Hartl, D.

Behr, J.

Eickelberg, O.