Mechanical strain exacerbates Pseudomonas infection in an organoid-based pneumonia-on-a-chip model

Using an advanced human lung-on-a-chip model, this study shows that increased mechanical strain can make the lungs more vulnerable to harmful bacteria such as Pseudomonas aeruginosa.

• Hoffmann, K.
• Behrendt, U.
• Pennitz, P.
• Kirsten, H.
• Pohl, J.
• Lopez-Rodriguez, E.
• Weissfuss, C.
• Kollmeier, J.
• Tönnies, M.
• Brill, S.
• Steinestel, K.
• Witzenrath, M.
• Wenzel, W.
• Zobel, C.
• Nouailles, G.