Activating mutations in PIK3CA, the gene encoding the catalytic p110
- Kumari, N.
- Wright, S. C.
- Witham, C. M.
- Monserrat, L.
- Palafox, M.
- Richard, J. L.
- Costa, C.
- Elkabets, M.
- Agostino, M.
- Klemm, T.
- Eccles, M.
- Garnham, A.
- Wu, T.
- Nilsson, J. A.
- Walz, N.
- Venugopal, V.
- Cerra, A.
- Vasilevski, N.
- Bridgeman, S.
- Bassi, S.
- Saei, A.
- Helal, M.
- Neundorf, P.
- Riedel, A.
- Rosenfeldt, M.
- Gill, J.
- Pahor, N.
- Hartmann, O.
- Chung, J.
- Sidhu, S. S.
- Moderau, N.
- Jha, S.
- Rodon, J.
- Diefenbacher, M. E.
- Komander, D.
- Serra, V.
- Eichhorn, P. J. A.
Keywords
- Humans
- *PTEN Phosphohydrolase/metabolism/genetics/antagonists & inhibitors
- *Breast Neoplasms/drug therapy/genetics/pathology/metabolism/enzymology
- Female
- *Drug Resistance, Neoplasm
- *Glycogen Synthase Kinase 3 beta/metabolism/genetics
- Animals
- Mice
- *Ubiquitin Thiolesterase/metabolism/genetics
- *Phosphoinositide-3 Kinase Inhibitors/pharmacology
- Cell Line, Tumor
- Signal Transduction/drug effects
- Class I Phosphatidylinositol 3-Kinases/genetics/metabolism/antagonists &
- inhibitors
- *Neoplasm Proteins/metabolism/genetics/antagonists & inhibitors
- Phosphatidylinositol 3-Kinases/metabolism/genetics
- Breast cancer
- Cell biology
- Oncology
- Signal transduction
- Ubiquitin-proteosome system
