RATIONALE: In the CLAIM study, dual bronchodilation with indacaterol/glycopyrronium (IND/GLY) significantly reduced hyperinflation, which translated into improved cardiac function, measured by left ventricular end-diastolic volume and cardiac output. Pulmonary microvascular blood flow (PMBF) is reduced in COPD; however, the effect of reduced lung hyperinflation on PMBF remains unknown. OBJECTIVES: To determine the effect of lung deflation with IND/GLY on PMBF and regional pulmonary ventilation using magnetic resonance imaging (MRI) in hyperinflated patients with COPD. METHODS: In this double-blind, randomized, two-period crossover study [
- Vogel-Claussen, J.
- Schonfeld, C. O.
- Kaireit, T. F.
- Voskrebenzev, A.
- Czerner, C. P.
- Renne, J.
- Tillmann, H. C.
- Berschneider, K.
- Hiltl, S.
- Bauersachs, J.
- Welte, T.
- Hohlfeld, J. M.
Keywords
- chronic obstructive pulmonary disease
- dual bronchodilation
- lung deflation
- pulmonary microvascular blood flow
- regional ventilation
