Senescence of lung mesenchymal stem cells of preterm infants by cyclic stretch and hyperoxia via p21

Phenotype distortion of lung resident mesenchymal stem cells (MSC) in preterm infants is a hallmark event in the pathogenesis of bronchopulmonary dysplasia (BPD). Here, we evaluated the impact of cyclic mechanical stretch (CMS) and hyperoxia (HOX). The negative action of HOX on proliferation and cell death was more pronounced at 80% than at 40%. Although the impact of CMS alone was modest, CMS plus HOX displayed the strongest effect sizes. Exposure to CMS and/or HOX induced the downregulation of PDGFR

• Behnke, J.
• Goetz, M. J.
• Holzfurtner, L.
• Korte, P.
• Weiss, A.
• Shahzad, T.
• Wilhelm, J.
• Schermuly, R. T.
• Rivetti, S.
• Bellusci, S.
• Ehrhardt, H.