Science and Research

dEREGulated pathways: Unraveling the role of epiregulin in skin, kidney and lung fibrosis

The epidermal growth factor receptor (EGFR) signaling pathway is an evolutionary conserved mechanism to control cell behavior during tissue development and homeostasis. Deregulation of this pathway has been associated with abnormal cell behavior, including hyperproliferation, senescence, and an inflammatory cell phenotype, thereby contributing to pathologies across a variety of organs, including kidney, skin, and lung. To date, there are seven distinct EGFR ligands described. While binding of these ligands to the receptor is cell type specific and spatio-temporally controlled with distinct affinities and kinetics, epiregulin (EREG) stands out as a long-acting EGFR ligand that emerges under pathological conditions, particularly in tissue fibrosis. Although EREG has been extensively studied in cancer, its contribution to maladaptive remodeling of a tissue is elusive. The aim of this review is to highlight the role of EREG in skin, kidney and lung fibrosis and to discuss opportunities for therapeutic intervention.

  • Ezaddoustdar, A.
  • Kalina, D.
  • Bielohuby, M.
  • Boehm, M.
  • Wygrecka, M.

Keywords

  • chronic inflammation
  • epidermial growth factor receptor
  • epiregulin
  • fibrosis
Publication details
DOI: 10.1152/ajpcell.00813.2024
Journal: Am J Physiol Cell Physiol
Work Type: Original
Location: UGMLC
Disease Area: PALI
Partner / Member: JLU
Access-Number: 39750963

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