Science and Research

Altered relaxation times in MRI indicate bronchopulmonary dysplasia

We developed a MRI protocol using transverse (T2) and longitudinal (T1) mapping sequences to characterise lung structural changes in preterm infants with bronchopulmonary dysplasia (BPD). We prospectively enrolled 61 infants to perform 3-Tesla MRI of the lung in quiet sleep. Statistical analysis was performed using logistic Group Lasso regression and logistic regression. Increased lung T2 relaxation time and decreased lung T1 relaxation time indicated BPD yielding an area under the curve (AUC) of 0.80. Results were confirmed in an independent study cohort (AUC 0.75) and mirrored by lung function testing, indicating the high potential for MRI in future BPD diagnostics. TRIAL REGISTRATION: DRKS00004600.

  • Forster, K.
  • Ertl-Wagner, B.
  • Ehrhardt, H.
  • Busen, H.
  • Sass, S.
  • Pomschar, A.
  • Naehrlich, L.
  • Schulze, A.
  • Flemmer, A. W.
  • Hubener, C.
  • Eickelberg, O.
  • Theis, F.
  • Dietrich, O.
  • Hilgendorff, A.

Keywords

  • paediatric lung disaese
Publication details
DOI: 10.1136/thoraxjnl-2018-212384
Journal: Thorax
Pages: 184-187 
Number: 2
Work Type: Original
Location: CPC-M
Disease Area: DPLD, PLI
Partner / Member: HGMU, JLU, LMU
Access-Number: 31048507
See publication on PubMed

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