Future exacerbations and mortality rates among patients experiencing COPD exacerbations: a meta-analysis of results from the EXACOS/AVOIDEX programme

OBJECTIVES: Exacerbations of chronic obstructive pulmonary disease (COPD) can lead to reduced lung function and worse clinical outcomes. Previous studies have reported associations between severe exacerbations and increased risk of hospitalisation and/or mortality. This meta-analysis examined the impact of moderate exacerbations on the risk of future exacerbations and all-cause mortality. DESIGN: This meta-analysis included seven observational studies from the EXACOS (EXAcerbations of COPD and their OutcomeS)/AVOIDEX (Impact of AVOIDing EXacerbations of COPD) programme studies. DATA SOURCES: This meta-analysis used data from regional claims databases or electronic healthcare records from seven countries. ELIGIBILITY CRITERIA: The individual studies included patients with a diagnosis of COPD and

• Rhodes, K.
• Patel, D.
• Duong, M. L.
• Haughney, J.
• Make, B. J.
• Marshall, J.
• Penz, E.
• Santus, P.
• Sethi, S.
• Soler-Cataluña, J. J.
• Sotgiu, G.
• Quint, J. K.
• Müllerová, H.
• Vogelmeier, C. F.
• Nordon, C.