Science and Research

The MHV-68 nuclear egress complex supports C-capsid selective capsid egress

Herpesvirus capsids assemble within the host nucleus and must traverse the nuclear envelope to undergo final envelopment in the cytoplasm. This exit strategy is orchestrated by the nuclear egress complex (NEC), a conserved heterodimeric protein complex that forms lattices that remodel the inner nuclear membrane. While the NEC is critical for efficient replication across

  • Sanders, S.
  • Schneider, C.
  • Soh, T. K.
  • Kotova, E.
  • Stalling, D.
  • Steer, B.
  • Reimer, R.
  • Ruzsics, Z.
  • Adler, H.
  • Bosse, J. B.

Keywords

  • Mhv-68
  • Nec
  • herpesvirus
  • murine gammaherpesvirus 68
  • nuclear egress complex
Publication details
DOI: 10.1128/jvi.00072-26
Journal: J Virol
Pages: e0007226 
Work Type: Original
Location: BREATH, CPC-M
Disease Area: General Lung and Other
Partner / Member: HMGU, MHH
Access-Number: 41995350


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