Therapeutic drug monitoring of osimertinib in non-small cell lung cancer and short bowel syndrome: a case report

Short bowel syndrome (SBS) following extensive intestinal resection is often characterized by impaired absorption of orally administered drugs, including tyrosine kinase inhibitors (TKI). We report the case of a patient with EGFR-mutated non-small cell lung carcinoma treated with 80 mg/d of the TKI osimertinib who achieved partial response of the tumor, but was subsequently subjected to a double-barreled jejunostomy due to ileus. Due to the development of SBS after the bypass surgery, plasma concentrations of osimertinib were monitored using mass spectrometry. The therapeutic drug monitoring confirmed a malabsorption of osimertinib in the patient (108 ng/mL, which is below the 5(th) percentile of the expected plasma concentration) and was useful to guide adjustments of TKI dosing in order to achieve adequate blood levels (161 ng/mL after increase of the dose to 120 mg/d) in order to maintain tumor control.

• Longuespée, R.
• Kunz, J.
• Fresnais, M.
• Foerster, K. I.
• Burhenne, J.
• Thomas, M.
• Kazdal, D.
• Stenzinger, A.
• Christopoulos, P.
• Haefeli, W. E.