Science and Research

Serum cystatin C and anti-N-methyl-D-aspartate receptor encephalitis

BACKGROUND: Cystatin C (CysC) is associated with many neurodegenerative disorders and autoimmune diseases, but its relationship with anti-N-Methyl-D-aspartate receptor (anti-NMDAR) encephalitis is unknown. METHODS: Serum levels of CysC were determined in 66 patients with anti-NMDAR encephalitis and 115 healthy controls. Of the 66 patients, 30 had a follow-up evaluation at 3 months after admission. Association of CysC with anti-NMDAR encephalitis and its clinical parameters were evaluated in the patients. RESULTS: The serum levels of CysC were significantly lower in patients with anti-NMDAR encephalitis than in controls (0.70 +/- 0.13 vs 0.83 +/- 0.17 mg/mL, P < .001). Disease severity and disease duration were significantly associated with CysC levels. Furthermore, a follow-up evaluation revealed that after treatment anti-NMDAR encephalitis patients had significantly increased serum CysC levels (P < .001) and significantly decreased modified Rankin Scale (mRS) scores (P < .001) compared with before treatment. In addition, a significant negative correlation was observed between the change in CysC levels and the change in mRS scores (r = -.700, P < .001). CONCLUSION: Our results show that the serum levels of CysC are associated with anti-NMDAR encephalitis and its clinical parameters and that the changes in CysC levels correlate with therapeutic effect. Therefore, our findings provide new insights into the association between serum CysC and anti-NMDAR encephalitis.
  • Shu, Y.
  • Chang, Y.
  • Wu, H.
  • Li, J.
  • Cao, B.
  • Sun, X.
  • Wang, J.
  • Peng, L.
  • Hu, X.
  • Yu, X.
  • Qiu, W.

Keywords

  • Adult
  • Anti-N-Methyl-D-Aspartate Receptor Encephalitis/*blood
  • Biomarkers/*blood
  • Cystatin C/*blood
  • Female
  • Humans
  • Male
  • Cystatin C
  • anti-N-Methyl-D-aspartate receptor encephalitis
  • autoimmune disorders
Publication details
DOI: 10.1111/ane.12894
Journal: Acta neurologica Scandinavica
Pages: 515-522 
Number: 5
Work Type: Original
Location: ARCN
Disease Area: General Lung and Other
Partner / Member: FZB
Access-Number: 29315460
See publication on PubMed

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