Forced expiratory volume in 1 second (FEV1 ) from spirometry, is the most commonly used parameter to detect early allograft dysfunction after lung transplantation (LTx). There are concerns regarding its sensitivity. Nitrogen-multiple breath washout (N2 -MBW) is sensitive at detecting early global (lung clearance index; LCI), and acinar (Sacin ) airway inhomogeneity. We investigated whether N2 -MBW indices indicate small airways pathology after LTx in children with stable spirometry. Thirty-seven children without BOS on median 1.6 (0.6-3.0) years after LTx, underwent N2 -MBW and spirometry, 28 of those on two occasions (
Nyilas, S.; Carlens, J.; Price, T.; Singer, F.; Muller, C.; Hansen, G.; Warnecke, G.; Latzin, P.; Schwerk, N.
