Virus-Induced Cellular Senescence Causes Pulmonary Sequelae Post-Influenza Infection

Influenza A virus (IAV) infection causes acute and long-term lung damage. Here, we used immunostaining, genetic, and pharmacological approaches to determine whether IAV-induced cellular senescence causes prolonged alterations in lungs. Mice infected with a sublethal dose of H1N1p2009 exhibited cellular senescence, as evidenced by increased pulmonary expression of p16, p21,

• Lipskaia, L.
• Delval, L.
• Sencio, V.
• Born, E.
• Heumel, S.
• Houssaini, A.
• Valentin, C.
• Raviola, S.
• Deruyter, L.
• Angulo, F. S.
• Gros, V.
• Marcos, E.
• Abid, S.
• Goekyildirim, M.
• Contreras, V.
• Flaman, J. M.
• Le Grand, R.
• Le Goffic, R.
• Bernard, D.
• Adnot, S.
• Trottein, F.