Science and Research

Effect of a biomimetic pathogen adsorbing device on inflammatory biomarkers in COVID-19 patients

INTRODUCTION: The Seraph 100 Microbind Affinity blood filter eliminate bacteria, viruses, fungi and toxins from blood stream. METHODS: This is a prospective multicenter observational biomarker trial in PCR-positive SARS-CoV-2 patients with acute respiratory failure. Biomarkers were sequentially tested at three time points. RESULTS: Forty-two patients with SARS-CoV-2 detected by PCR with acute respiratory failure were included. When receiving hemoperfusion treatment, 27 (64%) patients were on mechanical ventilation, 41 (98%) patients were treated in the ICU. The 3-month survival was 52%. After one hemoperfusion treatment cycle, D-dimer (p = 0.014), hemoglobin (p = 0.003) and LDH (p = 0.001) concentrations were significantly reduced 4 days after treatment. From the multiplex assay IL-1b, CXCL8/ IL-8, IL-10, IL-13, IL-15, CCL11/Eotaxin, G-CSF, and CXCL10/IP-10 were significantly reduced 1 h after treatment, however not 4 days later. CONCLUSION: Hemoperfusion with Seraph 100 Microbind Affinity Filter in patients with severe COVID-19 can transiently reduce several inflammatory biomarkers in the blood.

  • Schmieszek, J.
  • Fuehner, T.
  • Renger, I.
  • Welte, T.
  • Menne, J.
  • Fuge, J.
  • Van't Klooster, M. P.
  • Paul, A.
  • Siegert, A.
  • Borchina, D. N.
  • Falk, C. S.
  • Kielstein, J. T.

Keywords

  • Humans
  • *COVID-19/blood/therapy
  • Male
  • *Biomarkers/blood
  • Female
  • Prospective Studies
  • Aged
  • Middle Aged
  • *Hemoperfusion/methods
  • *SARS-CoV-2
  • Fibrin Fibrinogen Degradation Products/analysis/metabolism
  • Inflammation/blood
  • Respiration, Artificial
  • Covid‐19
  • SARS‐CoV‐2
  • biomarker
  • hemofilter
  • microbind affinity filter
Publication details
DOI: 10.1111/1744-9987.14137
Journal: Ther Apher Dial
Pages: 802-809 
Number: 5
Work Type: Original
Location: BREATH
Disease Area: PALI
Partner / Member: MHH
Access-Number: 38736311

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