We report the case of a 62-year-old woman with a history of ST-elevation myocardial infarction who underwent 68Ga-Pentixafor PET/CT for characterization of postinfarct myocardial inflammation. 68Ga-Pentixafor PET/CT incidentally demonstrated marked CXCR4 expression in a space-occupying lesion in the right upper lobe. Corresponding 18F-FDG PET/CT showed increased metabolism, and subsequent biopsy revealed non-small cell lung cancer. Immunohistochemistry confirmed that CXCR4 was highly expressed on tumor cells. 68Ga-Pentixafor is a novel CXCR4-targeted probe for PET imaging of CXCR4-positive tumors and holds promise for tumor staging and prognostic stratification. CXCR4-targeted radionuclide therapy represents a therapy option in metastasized diseases.
- Derlin, T.; Jonigk, D.; Bauersachs, J.; Bengel, F. M.
Keywords
- Carcinoma, Non-Small-Cell Lung/*diagnostic imaging
- *Coordination Complexes
- Female
- *Fluorodeoxyglucose F18
- Humans
- Lung Neoplasms/*diagnostic imaging
- Middle Aged
- Multimodal Imaging
- *Peptides, Cyclic
- *Positron-Emission Tomography
- Radiopharmaceuticals
- Tomography, X-Ray Computed
