Science and Research

Regional Lung Ventilation Analysis Using Temporally Resolved Magnetic Resonance Imaging

OBJECTIVE: We propose a computer-aided method for regional ventilation analysis and observation of lung diseases in temporally resolved magnetic resonance imaging (4D MRI). METHODS: A shape model-based segmentation and registration workflow was used to create an atlas-derived reference system in which regional tissue motion can be quantified and multimodal image data can be compared regionally. Model-based temporal registration of the lung surfaces in 4D MRI data was compared with the registration of 4D computed tomography (CT) images. A ventilation analysis was performed on 4D MR images of patients with lung fibrosis; 4D MR ventilation maps were compared with corresponding diagnostic 3D CT images of the patients and 4D CT maps of subjects without impaired lung function (serving as reference). RESULTS: Comparison between the computed patient-specific 4D MR regional ventilation maps and diagnostic CT images shows good correlation in conspicuous regions. Comparison to 4D CT-derived ventilation maps supports the plausibility of the 4D MR maps. Dynamic MRI-based flow-volume loops and spirograms further visualize the free-breathing behavior. CONCLUSIONS: The proposed methods allow for 4D MR-based regional analysis of tissue dynamics and ventilation in spontaneous breathing and comparison of patient data. The proposed atlas-based reference coordinate system provides an automated manner of annotating and comparing multimodal lung image data.

  • Kolb, C.
  • Wetscherek, A.
  • Buzan, M. T.
  • Werner, R.
  • Rank, C. M.
  • Kachelrie, M.
  • Kreuter, M.
  • Dinkel, J.
  • Heuel, C. P.
  • Maier-Hein, K.

Keywords

  • Aged
  • Computer Simulation
  • Female
  • Humans
  • Image Enhancement/methods
  • Image Interpretation, Computer-Assisted/*methods
  • Imaging, Three-Dimensional/*methods
  • Magnetic Resonance Imaging/*methods
  • Male
  • Middle Aged
  • Models, Biological
  • Pulmonary Fibrosis/*diagnostic imaging/physiopathology
  • *Pulmonary Ventilation
  • Reproducibility of Results
  • Respiratory-Gated Imaging Techniques/*methods
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed
Publication details
DOI: 10.1097/RCT.0000000000000450
Journal: J Comput Assist Tomogr
Pages: 899-906 
Number: 6
Work Type: Original
Location: CPC-M, TLRC
Disease Area: General Lung and Other
Partner / Member: DKFZ, Thorax
Access-Number: 27331925
See publication on PubMed

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