Science and Research

Recent developments in epigenetics of pediatric asthma

PURPOSE OF REVIEW: The goal of this review was to systematically analyze recent studies updating our knowledge on the role of epigenetic mechanisms in childhood asthma. RECENT FINDINGS: A systematic literature search was conducted that identified 23 fresh articles published within the last 5 years reporting the results of human studies on the relationships between epigenetic modifications and childhood asthma or its/related phenotypes. In almost all these studies, meaningful associations between levels of epigenetic marks (DNA methylation and/or histone modifications) and pediatric asthma or its/related phenotypes have been observed. In addition, many studies identified by our screening analyzed those associations in the context of environmental factors, such as pollution, tobacco smoke, farming, or diet, showing in a huge majority a modifying effect of those exposures. SUMMARY: The results of our systematic literature search provide a strong support for the role of epigenetic mechanisms in (mediating the effects of environmental exposure on) pediatric asthma. This knowledge may possibly be translated into diagnostic and/or therapeutic approaches.

  • Harb, H.; Alashkar Alhamwe, B.; Garn, H.; Renz, H.; Potaczek, D. P.
Publication details
DOI: 10.1097/MOP.0000000000000424
Journal: Current opinion in pediatrics
Pages: 754-763 
Number: 6
Work Type: Review
Location: UGMLC
Disease Area: AA
Partner / Member: UMR
Access-Number: 27662207
See publication on PubMed

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