Hypofractionated Stereotactic Radiotherapy versus Whole-Brain Radiotherapy following Brain Metastasis Resection - Results of the ESTRON Randomized Phase 2 Trial

BACKGROUND: Postoperative radiotherapy improves local control after brain metastasis (BM) resection. Whole-brain radiotherapy (WBRT) reduces recurrence risk but impairs neurocognition. Hypofractionated stereotactic radiotherapy of the cavity (HFSRT) may offer equivalent tumor control with reduced toxicity. ESTRON is the first randomized trial comparing post-operative HFSRT and WBRT. METHODS: This single-center phase 2 trial randomized 56 patients with resected BM to receive HFSRT (35 Gy in 7 fractions) or WBRT (30 Gy in 10 fractions). Patients could have

• El Shafie, R. A.
• Bernhardt, D.
• Welzel, T.
• Schiele, A.
• Schmitt, D.
• Thalmann, P.
• Erdem, S.
• Eichkorn, T.
• Paul, A.
• Lang, K.
• König, L.
• Weykamp, F.
• Adeberg, S.
• Lentz-Hommertgen, A.
• Jäkel, C.
• Bozorgmehr, F.
• Thomas, M.
• Sander, A.
• Kieser, M.
• Debus, J.
• Rieken, S.