Science and Research

Sex Differences in Vaccine-Induced Immunity and Protection Against Mycobacterium tuberculosis

Tuberculosis (TB) remains a leading global cause of death, with approximately 1.3 million fatalities annually. While males are more susceptible to TB, the underlying immune differences and their impact on vaccine efficacy are not fully understood. In this study, we vaccinated male and female C57BL/6 mice with BCG and 2 recombinant derivatives, VPM1002 and BCG

  • Harikumar Parvathy, G.
  • Hertz, D.
  • Bhandiwad, D.
  • Eggers, L.
  • von Borstel, L.
  • Behrends, J.
  • Hein, M.
  • Dreyer, V.
  • Marschner, J.
  • Orinska, Z.
  • Niemann, S.
  • Kaufmann, S. H. E.
  • Goldmann, T.
  • Lotter, H.
  • Flores-Valdez, M. A.
  • Schneider, B. E.

Keywords

  • Mycobacterium tuberculosis
  • Bcg
  • mouse model
  • sex differences
  • vaccination
Publication details
DOI: 10.1093/infdis/jiaf277
Journal: J Infect Dis
Work Type: Original
Location: ARCN
Disease Area: PALI
Partner / Member: FZB, Ghd
Access-Number: 40569757


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