OBJECTIVES: Lack of organ donors demands transplantation of older lung allografts for recipients between 0 and 50 years. So far, it has not yet been investigated whether donor-recipient age mismatch affects long-term outcome. METHODS: Records of patients aged between 0 and 50 years were retrospectively reviewed. Donor-recipient age mismatch was calculated subtracting recipient age from donor age. Univariate and multivariable Cox regression analysis was performed to assess donor-recipient age mismatch regarding the endpoints overall patient mortality, mortality conditioned to hospital discharge, biopsy confirmed rejection and chronic lung allograft dysfunction. Furthermore, we performed competing risk analysis to analyze if age mismatch affects biopsy confirmed rejection and CLAD while death being a competing risk. RESULTS: Between January 2010 and September 2021, out of 1363 patients who underwent lung transplantation at our institution, 409 patients fulfilled the eligibility criteria and were included. Age mismatch ranged between 0 and 56 years. Multivariable analysis revealed that donor-recipient age mismatch does not affect overall patient mortality (p = 0.19), biopsy confirmed rejection (p = 0.68) and chronic lung allograft dysfunction (p = 0.42). There was no difference seen in CLAD (p = 0.166) and biopsy confirmed rejection (p = 0.944) with the competing risk death (p = 0.765 and p = 0.851; respectively). CONCLUSIONS: Age mismatch between recipients and donors of lung allografts does not affect long term outcomes after lung transplantation.
- Franz, M.
- Aburahma, K.
- Avsar, M.
- Boethig, D.
- Greer, M.
- Alhadidi, H.
- Sommer, W.
- Tudorache, I.
- Warnecke, G.
- Haverich, A.
- Ius, F.
- Salman, J.
Keywords
- Lung transplantation
- graft selection
- long term outcomes
