Aim: This study assessed the utility of SPARC-like protein 1 (SPARCL1) as a biomarker of maladaptive right ventricular (RV) function in patients with pulmonary hypertension (PH).Methods: In this prospective study, we examined SPARCL1 levels in 105 patients with adaptive (n = 34) and maladaptive RV (n = 32) pressure overload caused by PH, dilated cardiomyopathy (DCM, n = 18) with LVEF < 35% and preserved RV function and controls without LV or RV abnormalities (n = 21).Results: The median SPARCL1 concentration in patients with maladaptive RV function was higher than in those with adaptive RV function (p < 0.01), DCM (p < 0.001) or controls (p < 0.001). Patients with adaptive RV function had higher SPARCL1 concentrations than controls (p < 0.05), whereas there was no difference between adaptive RV and DCM. SPARCL1 showed good predictive power for maladaptive RV (AUC 0.77, p < 0.001) with an optimal cut-off value of 9.66 ng/ml. The TAPSE/PASP ratio was the only independent predictor of SPARCL1 >/= 9.66 ng/ml in multivariable logistic regression analysis.Conclusion: SPARCL1 shows potential as novel biomarker of RV pathological remodelling and is associated with RV maladaptation and ventriculoarterial uncoupling in PH.
- Keranov, S.
- Dorr, O.
- Jafari, L.
- Liebetrau, C.
- Keller, T.
- Troidl, C.
- Kriechbaum, S.
- Voss, S.
- Richter, M.
- Tello, K.
- Gall, H.
- Ghofrani, H. A.
- Mayer, E.
- Seeger, W.
- Hamm, C. W.
- Nef, H.
Keywords
- Sparcl1
- Tapse/pasp
- adaptive and maladaptive right ventricular pressure overload
- cardiac remodelling
- ventriculoarterial uncoupling pulmonary hypertension
