Glycan microarray analysis of Candida-related antibodies in human and mice sera guides biomarker discovery and vaccine development

Invasive, high-mortality yeast infections caused by pathogenic Candida species are the most common fungal nosocomial bloodstream infections. The World Health Organization (WHO) has called for improved prevention and diagnostic strategies for fungal pathogens. Here, we demonstrate that Candida-related antibodies can be detected using glycan microarrays containing synthetic glycans to guide the discovery of oligosaccharide epitopes for diagnostics and vaccine design. Pure, synthetic mannans and

• Reuber, E. E.
• Hickey, E.
• Pradhan, A.
• Sprute, R.
• Lingscheid, T.
• Tober-Lau, P.
• Leaves, I.
• Stappers, M. H. T.
• Kurth, F.
• Bruno, M.
• Netea, M. G.
• Sander, L. E.
• Cornely, O. A.
• Gow, N. A. R.
• Brown, A. J. P.
• Singh, R. K.
• Omoregbee-Leichnitz, S.
• Sletten, E. T.
• Danglad-Flores, J.
• Seeberger, P. H.