Science and Research

High-resolution multimodal imaging reveals spatial and temporal heterogeneity of airway mucus plugging in mice with muco-obstructive lung disease

Mucus plugging is a hallmark of muco-obstructive lung diseases; however, the spatiotemporal dynamics of plug formation remain poorly understood. We used a multimodal high-resolution imaging approach to study mucus plugging in newborn (0-1 days), juvenile (13-16 days), and adult (49-59 days)

  • Benke, C. V.
  • Duerr, J.
  • Engel, A.
  • Dullin, C.
  • Stiller, W.
  • Horstmann, H.
  • Redenbach, C.
  • Ackermann, M.
  • Kauczor, H. U.
  • Kuner, T.
  • Wielpütz, M. O.
  • Mall, M. A.
  • Wagner, W. L.

Keywords

  • Animals
  • *Mucus/metabolism
  • Mice
  • X-Ray Microtomography
  • Mice, Transgenic
  • *Multimodal Imaging/methods
  • *Lung/diagnostic imaging/pathology/metabolism
  • *Lung Diseases, Obstructive/diagnostic imaging/pathology/metabolism
  • Disease Models, Animal
  • Epithelial Sodium Channels/genetics/metabolism
  • Microscopy, Electron, Scanning
  • Airway obstruction
  • Cystic fibrosis
  • ENaC
  • Micro-CT
  • Mucus plugging
  • Synchrotron tomography
Publication details
DOI: 10.1038/s41598-025-22537-7
Journal: Sci Rep
Pages: 41760 
Number: 1
Work Type: Original
Location: Assoziierter Partner, TLRC
Disease Area: CFBE, PLI
Partner / Member: BIH, UKHD
Access-Number: 41286000


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