Mucus plugging is a hallmark of muco-obstructive lung diseases; however, the spatiotemporal dynamics of plug formation remain poorly understood. We used a multimodal high-resolution imaging approach to study mucus plugging in newborn (0-1 days), juvenile (13-16 days), and adult (49-59 days)
- Benke, C. V.
- Duerr, J.
- Engel, A.
- Dullin, C.
- Stiller, W.
- Horstmann, H.
- Redenbach, C.
- Ackermann, M.
- Kauczor, H. U.
- Kuner, T.
- Wielpütz, M. O.
- Mall, M. A.
- Wagner, W. L.
Keywords
- Animals
- *Mucus/metabolism
- Mice
- X-Ray Microtomography
- Mice, Transgenic
- *Multimodal Imaging/methods
- *Lung/diagnostic imaging/pathology/metabolism
- *Lung Diseases, Obstructive/diagnostic imaging/pathology/metabolism
- Disease Models, Animal
- Epithelial Sodium Channels/genetics/metabolism
- Microscopy, Electron, Scanning
- Airway obstruction
- Cystic fibrosis
- ENaC
- Micro-CT
- Mucus plugging
- Synchrotron tomography