Mesenchymal stromal cells (MSCs) are multipotent adult stem cells which possess immunomodulatory and repair capabilities. In this study, we investigated whether MSC therapy could modulate inflammation and lung damage in the lungs of Scnn1b-transgenic mice overexpressing the
- Doherty, D. F.
- Roets, L. E.
- Dougan, C. M.
- Brown, R. R.
- Hawthorne, I. J.
- O'Kane, C.
- Krasnodembskaya, A. D.
- Mall, M. A.
- Taggart, C. C.
- Weldon, S.
Keywords
- Animals
- *Cystic Fibrosis/therapy/metabolism/pathology
- *Mesenchymal Stem Cells/metabolism
- *Disease Models, Animal
- *Mesenchymal Stem Cell Transplantation/methods
- Mice
- Humans
- *Mice, Transgenic
- Lung/pathology/metabolism
- Epithelial Sodium Channels/metabolism/genetics
- Inflammation/therapy/pathology/metabolism
- PPAR gamma/metabolism
- Bronchoalveolar Lavage Fluid
- Cytokines/metabolism
- Emphysema
- Inflammation
- Mesenchymal Stromal Cell
- Peroxisome proliferator-activated receptor-γ
