Exploring alveolar recruitability using positive end-expiratory pressure in mice overexpressing TGF-

Pre-injured lungs are prone to injury progression in response to mechanical ventilation. Heterogeneous ventilation due to (micro)atelectases imparts injurious strains on open alveoli (known as volutrauma). Hence, recruitment of (micro)atelectases by positive end-expiratory pressure (PEEP) is necessary to interrupt this vicious circle of injury but needs to be balanced against acinar overdistension. In this study, the lung-protective potential of alveolar recruitment was investigated and balanced against overdistension in pre-injured lungs. Mice, treated with empty vector (AdCl) or adenoviral active TGF-

• Roeder, F.
• Röpke, T.
• Steinmetz, L. K.
• Kolb, M.
• Maus, U. A.
• Smith, B. J.
• Knudsen, L.